Curriculum Vitae

Charles Brenner, PhD

Roy J. Carver Chair of Biochemistry and Professor of Internal Medicine

Carver College of Medicine
University of Iowa
51 Newton Road
4-403 Bowen Science Building (BSB)
Iowa City, IA 52242

Office Phone: (319) 335-7934
Lab Phone: (319) 384-4099
Email: charles-brenner@uiowa.edu

Education

Undergraduate

• Wesleyan University (1979-1983)
  Middletown, CT 06457
  B.A. with Honors in Biology

Graduate

• Stanford University School of Medicine (1988-1993)
  Stanford, CA 94305
  Ph.D. in Cancer Biology
  Thesis: "Specificity and Activity of the Kex2 Protease: From Yeast Genetics to Enzyme Kinetics"
  Supervisor: Professor Robert S. Fuller
  Department of Biochemistry

Post-doctoral

• Brandeis University (1993-1996)
  Waltham, MA 02254
  Supervisors: Professors Dagmar Ringe and Gregory A. Petsko
  Departments of Chemistry and Biochemistry

Selected Honors and Awards

• 1979-1980 Connecticut State Scholar
• 1979-1983 National Merit Scholar
• 1988-1992 Program in Cancer Biology trainee of the NCI
• 1993-1996 Fellow of the Leukemia Society of America
• 1994 Leukemia Society of America Short-Term Scientific Exchange Award
• 1997-present National Cancer Institute, CA075954, Functional and Structural Analysis of HIT Proteins/ Mechanism of Dnmtl Up-regulation by Fhit Loss
• 1998-2000 Basil O'Connor Scholar of the March of Dimes Birth Defects Foundation
• 1998-2000 Beckman Young Investigator of the Arnold and Mabel Beckman Foundation
• 1998-2001 Burroughs Wellcome Fund New Investigator in the Basic Pharmacological Sciences
• 2007 William E.M. Lands Lecturer in Nutritional Biochemistry, University of Michigan
• 2008-2009 Lung Cancer Research Foundation Award
• 2010- present Roy J. Carver Chair of Biochemistry
• 2012 Holden Comprehensive Cancer Center Oberley Award
• 2013 Fellow of the American Association for the Advancement of Science
• 2014 State of Iowa Regents Award for Faculty Excellence
• 2015 Ackerson Student Lecturer in Biochemistry & Redox Biology, University of Nebraska
• 2015 Keynote Lecturer at the Brown University Pathobiology Retreat
• 2016 ASBMB Award for Exemplary Contributions to Education
• 2016 CNIO Distinguished Lecturer, Madrid
• 2018 Dartmouth Technology Transfer Innovation and Commercialization Award
• 2018 Keynote Lecturer at 15th International Symposium on Milk Genomics & Human Health, Sacramento
• 2019 Keynote Lecturer at  Norway AGE Conference on NAD, Oslo
• 2020 Mary Swartz Rose Senior Investigator Award, American Society of Nutrition

National Service

• 1998 Organizer of Wesleyan University Alumni Symposium on Biology and the New Pharmacopaeia
• 2004-2007 F04B, Biophysical and Biochemical Sciences Fellowship Study Section, National Institutes of Health
• 2004 Structural Biology Program, Department of Energy
• 2005-2007 Beckman Young Investigator Review Committee, Arnold and Mabel Beckman Foundation
• 2008 American Federation for Aging Research National Scientific Advisory Council
• 2008-present ICP1, International Cooperative Projects Study Section, National Institutes of Health
• 2009-2012 ASBMB Publications Committee (chair, 2011-2012)
• 2012-present ASBMB representative to AAMC Council of Academic Societies 
• 2014-present Scientific Advisory Board, ChromaDex, Inc
• 2016-2017 Co-founder and Chief Scientific Advisor, Prohealthspan, LLC
• 2017-present Chief Scientific Adviser, ChromaDex, Inc
• 2017-present Scientific Advisory Board, Cytokinetics, Inc

Professional Experience

• 1983-1985 Research Associate for Anthony J. Brake
  Chiron Corporation, Emeryville, CA
• 1986-1988 Research Associate for Kunihiro Matsumoto
  DNAX Research Institute, Palo Alto, CA
• 1996-2000 Assistant Professor of Microbiology & Immunology
  Jefferson Medical College
  Member, Program in Structural Biology, Kimmel Cancer Center
• 2000-2003 Associate Professor of Microbiology & Immunology
  Jefferson Medical College
  Director, Structural Biology & Bioinformatics Program, Kimmel Cancer Center
  Thomas Jefferson University, Philadelphia, PA
• 2003-2007 Associate Professor of Genetics and of Biochemistry
  Dartmouth Medical School
• 2003-2008 Director, Cancer Mechanisms Program
  Norris Cotton Cancer Center
• 2005-2009 Scientific Director
  Comprehensive Thoracic Oncology Program
  Dartmouth-Hitchcock Medical Center
• 2007-2009 Professor of Genetics and of Biochemistry
  Dartmouth Medical School
• 2008-2009 Associate Director for Basic Sciences
  Norris Cotton Cancer Center, Lebanon, NH
• 2009-present Professor and DEO of Biochemistry
  Carver College of Medicine
  University of Iowa, Iowa City, IA
• 2010-present Professor of Internal Medicine and Roy J. Carver Chair in Biochemistry
  Carver College of Medicine
  University of Iowa, Iowa City, IA
• 2011-2020 Founding Co-Director, Obesity Research and Education Initiative
  Office of the Provost
  University of Iowa, Iowa City, IA

Teaching

• 1997-2003 Yeast Transformation section of BI532
• 1997-2003 X-ray Crystallography section of PR613 including the Difference Patterson Function
• 1999-2003 Yeast Genetics section of GE611
• 1999-2003 Yeast Cell Cycle and Cell Cycle Checkpoints section of GE636
• 2004-2009 NAD+ Metabolism section of the MCB Core Course
• 2005-2008 Genetics 144, Oncogenomics
• 2005-2007 Yeast Genetics section of the MCB Core Course
• 2010-2018 Carbohydrate Metabolism Section of BIOC:3120
• 2019-present Lipid and nucleotide metabolism section of BIOC:3130

Publications

1. A. Brake, C. Brenner, R. Najarian, P. Laybourn & J. Merryweather, "Structure of Genes Encoding Precursors of the Yeast Peptide Mating Pheromone a-Factor" in Protein Transport and Secretion, M. J. Gething, ed., pp. 103-108 (1985). Download pdf reprint
2. I. Miyajima, M. Nakafuku, N. Nakayama, C. Brenner, A. Miyajima, K. Kaibuchi, K. Arai, Y. Kaziro & K. Matsumoto, "GPA1, A Haploid-Specific Essential Gene, Encodes a Yeast Homolog of Mammalian G Protein Which May Be Involved in Mating Factor Signal Transduction," Cell, v. 50, pp. 1011-1019 (1987). Download pdf reprint
3. C. Brenner, N. Nakayama, M. Goebl, K. Tanaka, A. Toh-e & K. Matsumoto, "CDC33 Encodes mRNA Cap-Binding Protein eIF-4E of Saccharomyces cerevisiae," Mol Cell Biol, v. 8, pp. 3556-3559 (1988). Download pdf reprint
4. K. Matsumoto, M. Nakafuku, N. Nakayama, I. Miyajima, K. Kaibuchi, A. Miyajima, C. Brenner, K. Arai & Y. Kaziro, "The Role of G Proteins in Yeast Signal Transduction," Cold Spring Harbor Symp Quant Biol, v. 53, pp. 567-575 (1988). Download pdf reprint
5. R.S. Fuller, C. Brenner, P. Gluschankof & C.A. Wilcox, "The Yeast Prohormone-Processing Kex2 Protease, an Enzyme with Specificity for Paired Basic Residues," in Methods in Protein Sequence Analysis, Jornvall, H., Hoog, J.-O. & Gustavsson, A.-M., pp. 205-214 (1991). Download pdf reprint
6. C. Brenner & R.S. Fuller, "Structural and Enzymatic Characterization of a Purified Prohormone-Processing Enzyme: Secreted, Soluble Kex2 Protease," Proc Natl Acad Sci, v. 89, pp. 922-926 (1992). Download pdf reprint
7. H. Angliker, P. Wikstrom, E. Shaw, C. Brenner & R.S. Fuller, "The Synthesis of Inhibitors of Processing Proteases and Their Action on the Kex2 Protease of Yeast," Biochem J, v. 293, pp. 75-81 (1993). Download pdf reprint
8. C. Brenner, A. Bevan & R.S. Fuller, "One-Step Site-Directed Mutagenesis of The Kex2 Protease Oxyanion Hole,"Current Biology, v. 3, pp. 498-506 (1993). Download pdf reprint
9. C. Brenner, A. Bevan & R. S. Fuller, "Methods for Analyzing the Specificity and Activity of a Prohormone-Processing Enzyme, the Yeast Kex2 Protease (Kexin)," Meth Enz, v. 244, pp. 152-167 (1994). Download pdf reprint
10. C. Brenner, "Reducing the Energy Barrier to Crystallization, review of Crystallization of Nucleic Acids and Proteins,"Protein Science, v. 3, pp. 2471-2472 (1994). Download pdf reprint
11. H. Diefenbach-Jagger, C. Brenner, B.E. Kemp, W. Baron, J. McLean, T.J. Martin & J.M. Moseley, "Arg21 is the Preferred Kexin Cleavage Site in Parathyroid-Hormone-Related Protein," Eur J Biochem, v. 229, pp. 91-98 (1995). Download pdf reprint
12. C. Brenner, P. Garrison, J. Gilmour, D. Peisach, D. Ringe, G.A. Petsko & J.M. Lowenstein, "Crystal Structures of Hint Demonstrate that Histidine Triad Proteins are GalT-related Nucleotide-Binding Proteins," Nature Structural Biology, v. 4, pp. 231-238 (1997). View Hint-GMP, Hint-Adenosine, Hint-8-Br-AMP, Apo-Hint entries at the Protein Data Bank. Download pdf reprint
13. C. Brenner, H.C. Pace, P.N. Garrison, A.K. Robinson, A. Rosler, X.H. Liu, G.M. Blackburn, C.M. Croce, K. Huebner & L.D. Barnes, "Purification and Crystallization of Complexes Modeling the Active State of the Fragile Histidine Triad Protein," Protein Engineering, v. 10, pp. 1461-1463 (1997). Download pdf reprint
14. G.M. Blackburn, X. Liu, A. Rosler & C. Brenner, "Two Hydrolase Resistant Analogues of Diadenosine 5',5'''-P1,P3-triphosphate for Studies with Fhit, the Human Fragile Histidine Triad Protein," Nucleosides and Nucleotides, v. 17, pp. 301-308 (1998). Download pdf reprint
15. H.C. Pace, P.N. Garrison, A.K. Robinson, L.D. Barnes, A. Draganescu, A. Rosler, G.M. Blackburn, Z. Siprashvili, C.M. Croce, K. Huebner & C. Brenner, "Genetic, Biochemical and Crystallographic Characterization of Fhit-Substrate Complexes as the Active Signaling Form of Fhit," Proc Natl Acad Sci, v. 95, pp. 5484-5489 (1998). View Fhit-IB2, Fhit H96N-IB2 entries at the Protein Data Bank. Download pdf reprint
16. Y. Pekarsky, M. Campiglio, Z. Siprashvili, T. Druck, Y. Sedkov, S. Tillib, A. Draganescu, P. Wermuth, J.H. Rothman, K. Huebner, A.M. Buchberg, A. Mazo, C. Brenner & C.M. Croce, "Nitrilase and Fhit Homologs are Encoded as Fusion Proteins in Drosophila melanogaster and Caenorhabditis elegans," Proc Natl Acad Sci, v. 95, pp. 8744-8749 (1998). Download pdf reprint
17. A. Bevan, C. Brenner & R.S. Fuller, "Quantitative Assessment of Enzyme Specificity in vivo: P₂ Recognition by Kex2 Protease Defined in a Genetic System," Proc Natl Acad Sci, v. 95, pp. 10384-10389 (1998). Download pdf reprint
18. X. Liu, C. Brenner, A. Guranowski, E. Starzynska & G.M. Blackburn, "New Tripodal, 'Supercharged Analogs' of Adenosine Nucleotides: Inhibitors for the Fhit Ap₃A Hydrolase," Angew Chem Int Ed, v. 38, pp. 1244-1247 (1999). Download pdf reprint(set printer for A4 layout and/or "Shrink To Fit").
19. C. Brenner, "Fhit-Substrate Complexes: A New Paradigm in Reversible Protein Phosphorylation," Proceedings of theXIVth International Conference on Phosphate Chemistry, Phosphorus, Sulfur and Silicon, v. 144-146, pp. 745-748 (1999). Download pdf reprint
20. K. Huebner, G. Sozzi, C. Brenner, M.A. Pierotti & C.M. Croce, "Fhit Loss in Lung Cancer: Diagnostic and Therapeutic Implications," Advances in Oncology, v. 15, pp. 3-10 (1999). Download pdf huebner99(9.2 MB file).
21. M.J. Fernandes, A.A. Finnegan, L.D. Siracusa, C. Brenner, N.N. Iscove & B. Calabretta, "Characterization of a Novel Receptor that Maps Near the Natural Killer Gene Complex: Demonstration of Carbohydrate Binding and Expression in Hematopoietic Cells," Cancer Research, v. 59, pp. 2709-2717 (1999). Download pdf reprint
22. C. Brenner, P. Bieganowski, H.C. Pace & K. Huebner, "The Histidine Triad Superfamily of Nucleotide-Binding Proteins," J Cellular Physiology, v. 181, pp. 179-187 (1999). Download pdf reprint. Please see ref. 38 for the most current review on HIT proteins.
23. A. Draganescu, S.C. Hodawadekar, K.R. Gee & C. Brenner, "Fhit-Nucleotide Specificity Probed with Novel Fluorescent and Fluorogenic Substrates," J Biol Chem, v. 275, pp. 4555-4560 (2000). Download pdf reprint The reagents can be ordered from Molecular Probes, Inc.
24. C. Brenner, "A Cultivated Taste for Yeast," Genome Biology, v. 1, pp. reviews103.1-103.4 (2000). Download pdf reprint
25. C. Brenner, "Fhitness and Cancer in the Mouse," Trends in Genetics, v. 16, p. 294 (2000). Download pdf reprint
26. H.C. Pace, S.C. Hodawadekar, A. Draganescu, J. Huang, P. Bieganowski, Y. Pekarsky, C.M. Croce & C. Brenner, "Crystal Structure of the Worm NitFhit Rosetta Stone Protein Reveals a Nit Tetramer Binding Two Fhit Dimers," Current Biology, v. 10, pp. 607-617 (2000). View NitFhit at the Protein Data Bank. Download pdf reprint
27. C. Brenner, "Condensing the RNA World," Trends in Biochemical Sciences, v. 25, p. 485 (2000). Download pdf reprint
28. J.R. Boyne, H.M. Yosuf, P. Bieganowski, C. Brenner & C. Price, "Yeast Myosin Light Chain, Mlc1p, Interacts with Both IQGAP and Class II Myosin to Effect Cytokinesis," J Cell Science, v. 113, pp. 4533-4543 (2000). Download pdf reprint
29. H.C. Pace & C. Brenner, "The Nitrilase Superfamily: Classification, Structure and Function," Genome Biology, v. 2, pp. reviews0001.1-0001.9 (2001). Download pdf reprint. See supplemental data file at Genome Biology.
30. L. Daheron, T. Zenz, L.D. Siracusa, C. Brenner & B. Calabretta, " Molecular Cloning of Ian4: a BCR/ABL-Induced Gene that Encodes an Outer Membrane Mitochondrial Protein with GTP-Binding Activity, " Nucleic Acids Research, v. 29, pp. 1308-1316 (2001). Download pdf reprint
31. A.G. McLennan, L.D. Barnes, G.M. Blackburn, C. Brenner, A. Guranowski, A.D. Miller, J.M. Rovira, P. Rotllan, B. Soria, J.A. Tanner & A. Sillero, "Recent Developments in the Study of the Intracellular Function of Diadenosine Polyphosphates," Drug Development Research, v. 52, pp. 249-259 (2001). Download pdf reprint
32. J.M. Varnum, J. Baraniak, R. Kaczmarek, W.J. Stec & C. Brenner, "Di-, Tri- and Tetra-5-O-Phosphorothioadenosyl Substituted Polyols as Inhibitors of Fhit: Importance of the Alpha-Beta Bridging Oxygen and Beta Phosphorus Replacement, " BMC Chemical Biology, v. 1, 3 (2001). Download pdf reprint
33. C. Brenner, "FHIT" in the Wiley Encyclopedia of Molecular Medicine, v. 2, Thomas E. Creighton, Ed., pp. 1274-1275 (2001). Download pdf reprint
34. D.H. Klaubert, K.R. Gee & C.M. Brenner, "Phosphate-Bound Polyazaindacene Derivatives of Nucleotides," US Patent 6,323,186, issued November 27, 2001. Download pdfreprint
35. S.K. Milano, H.C. Pace, Y.-M. Kim, C. Brenner & J. Benovic, "Scaffolding Functions of Arrestin-2 Revealed by Crystal Structure and Mutagenesis," Biochemistry, v. 41, pp. 3321-3328 (2002). View Arrestin-2 at the Protein Data Bank. Download pdf reprint
36. P. Bieganowski, P.N. Garrison, S.C. Hodawadekar, G. Faye, L.D. Barnes & C. Brenner, "Adenosine Monophosphoramidase Activity of Hint and Hnt1 Supports Function of Kin28, Ccl1 and Tfb3, " J Biol Chem, v. 277, pp. 10852-10860 (2002). Download pdf reprint
37. M. Rubio-Texeira, J.M. Varnum, P. Bieganowski & C. Brenner, "Control of Dinucleoside Polyphosphates by the FHIT-Homologous HNT2 Gene, Adenine Biosynthesis, and Heat Shock in Saccharomyces cerevisiae," BMC Molecular Biology, v. 3, 7 (2002). Download pdf reprint
38. C. Brenner, "Hint, Fhit and GalT: Function, Structure, Evolution and Mechanism of Three Branches of the Histidine Triad Superfamily of Nucleotide Hydrolases and Transferases," Biochemistry, v. 41, pp. 9003-9014 (2002). Download pdf reprint
39. C. Brenner, "Catalysis in the Nitrilase Superfamily," Current Opinion in Structural Biology, v. 6, pp. 775-782 (2002). Download pdf reprint
40. A. Owczarek, R. Kaczmarek, B. Mikolajczyk, E. Wasilewska, D. Korczynski, J. Baraniak, M. Koziolkiewicz, W.J. Stec WJ & C. Brenner, "Stereochemical analysis of diastereomeric 1,3-bis(adenosine-5'-O-phosphorothioyl)glycerols,"Nucleosides, Nucleotides and Nucleic Acids, v. 22, pp. 797-9 (2003).
41. F. Trapasso, A. Krakowiak, R. Cesari, J. Arkles, S. Yendamuri, H. Ishii, A. Vecchione, T. Kuroki, P. Bieganowski, H.C. Pace, K. Huebner, C.M. Croce & C. Brenner, "Designed FHIT Alleles Establish that Fhit-Induced Apoptosis in Cancer Cells is Limited by Substrate-Binding," Proc Natl Acad Sci, v. 100, pp. 1592-1597 (2003). Download pdf reprint
42. H.C. Pace & C. Brenner, "Feminizing Chicks: A Model for Avian Sex Determination Based on Titration of Hint Enzyme Activity and the Predicted Structure of an Asw-Hint Heterodimer," Genome Biology, v. 4, R18 (2003). Download pdf reprint
43. P. Bieganowski, H.C. Pace & C. Brenner, "Eukaryotic NAD+ Synthetase Qns1 Contains an Essential, Obligate Intramolecular Thiol Glutamine Amidotransferase Domain Related to Nitrilase," J Biol Chem, v. 278, pp. 33049-33055 (2003). Download pdf reprint
44. P. Bieganowski & C. Brenner, "The Reported Human NADsyn2 is Ammonia-Dependent NAD+ synthetase from a Pseudomonad," J Biol Chem, v. 278, pp. 33056-33059 (2003). Download pdfreprint
45. C. Brenner, "Subtleties Among Subtilases: Structural Biology of Kex2 and Furin-Related Prohormone Convertases,"EMBO Reports, v. 4, pp. 937-938 (2003). Download pdf reprint
46. D.A. Kwasnicka, A. Krakowiak, C. Thacker, C. Brenner & S.R. Vincent, " Coordinate Expression of NADPH-Dependent Flavin Reductase, FRE-1, and Hint-Related 7meGMP-Directed Hydrolase, DCS-1," J Biol Chem, v. 278, pp. 39051-39058 (2003). Download pdf reprint
47. A. Krakowiak, H.C. Pace, G. Michael Blackburn, M. Adams, A. Mekhalfia, R. Kaczmarek, J. Baraniak, W.J. Stec & C. Brenner, "Biochemical, Crystallographic and Mutagenic Characterization of Hint, the AMP-Lysine Hydrolase, with Novel Substrates and Inhibitors," J Biol Chem, v. 279, pp. 18711-18716 (2004). View Hint-N-ethylsulfamoyl adenosine at the Protein Data Bank. Download pdf reprint
48. C. Brenner, "Precariously on the Cusp of Oncogenomics," chapter 1 of Oncogenomics: Molecular Approaches to Cancer, C. Brenner and D. Duggan, Eds., John Wiley & Sons, (2004). View the Oncogenomics poster the site at Wiley, or Amazon. Download pdf book review in the New England Journal of MedicineNEJMreview.pdf
49. T.M. Maiolatesi & C. Brenner, "Chemical and Genetic Methods to Validate Targets in Non-Mammalian Organisms," chapter 10 of Oncogenomics: Molecular Approaches to Cancer, C. Brenner and D. Duggan, Eds., John Wiley & Sons, (2004). View the Oncogenomics poster, the site at Wiley, or Amazon. Download pdf book review in the New England Journal of Medicine.
50. P. Bieganowski & C. Brenner, "Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans," Cell, v. 117, pp. 495-502 (2004). Download pdf reprint
51. P. Bieganowski, K. Shilinski, P.N. Tsichlis & C. Brenner, "Cdc123 and Checkpoint Forkhead Associated With RING Proteins Control the Cell Cycle By Controlling eIF2gamma Abundance, " J Biol Chem, v. 279, pp. 44656-44666 (2004). Download pdf reprint
52. C. Brenner, "Chemical Genomics in Yeast," Genome Biology, v. 5, 240 (2004). Download pdf reprint
53. P.M. Clements, C. Breslin, E.D. Deeks, P.J. Byrd, L. Ju, P. Bieganowski, C. Brenner, M.-C. Moreira, A.M.R. Taylor & K.W. Caldecott, "The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4," DNA Repair, v. 3, pp. 1493-1502 (2004). Download pdf reprint
54. K.P. Parks, H. Seidle, N. Wright, J.B. Sperry, P. Bieganowski, K. Howitz, D.L. Wright & C. Brenner, "Altered Specifity of Hint-W123Q Supports a Role for Hint Inhibition by Asw in Avian Sex Determination," Physiological Genomics, v. 20, pp. 12-14 (2004). Download pdf reprint and supplemental data
55. T.-F. Chou, P. Bieganowski, K. Shilinski, J. Cheng, C. Brenner & C.R. Wagner, "³¹P NMR and Genetic Analysis Establish hinT as the only E. coli Purine Nucleoside Phosphoramidase and as Essential for Growth Under High Salt Conditions," J Biol Chem, v. 280, pp. 15356-15361 (2005). Download pdf chou05.pdfreprint and supplemental data
56. H.F. Seidle, P. Bieganowski & C. Brenner, "Disease-Associated Mutations Inactivate AMP-Lysine Hydrolase Activity of Aprataxin," J Biol Chem, v. 280, pp. 20927-20931 (2005). View or download JBC Paper of the Week Summary. Download pdfseidle05.pdfreprint and supplemental data
57. C. Brenner, "Evolution of NAD Biosynthetic Enzymes," Structure, v. 13, pp. 1239-1240 (2005). Download pdf reprint
58. K.L. Bogan & C. Brenner, "Fhit," AfCS-Nature Molecule Pages (2006), [doi:10.1038/mp.a000914.01].
59. S.K. Milano, Y.-M. Kim, F.P. Stefano, J.L. Benovic & C. Brenner, "Nonvisual Arrestin Oligomerization and Cellular Localization are Regulated by Inositol Hexakisphosphate Binding," J Biol Chem, v. 281, pp. 9812-9823 (2006). View Arrestin-2-IP6 entry at the Protein Data Bank. Download pdf reprint and supplemental data
60. J. Martin, F. Magnino, K. Schmidt, A.-C. Piguet, J.-S. Lee, D. Semela, M.V. St-Pierre, A. Ziemiecki, D. Cassio, D. Mochly-Rosen, C. Brenner, S.S. Thorgeirsson & J.-F. Dufour, "Hint2, a Mitochondrial Apoptotic Sensitizer Downregulated in Hepatocellular Carcinoma," Gastroenterology, v. 130, pp. 2179-2188 (2006). Download pdf reprint
61. P. Bieganowski, H.F. Seidle, M. Wojcik & C. Brenner, "Synthetic Lethal and Biochemical Analyses of NAD and NADH Kinases in Saccharomyces cerevisiae Establish Separation of Cellular Functions," J Biol Chem, v. 281, pp. 22439-22445 (2006). Download pdf reprint
62. A.B. Parsons, A. Lopez, I.E. Givoni, D.E. Williams, C.A. Gray, J. Porter, G. Chua, R. Sopko, R.L. Brost, C.-H. Ho, J. Wang, T. Ketela, C. Brenner, J.A. Brill, G.E. Fernandez, T.C. Lorenz, G.S. Payne, S. Ishihara, Y. Ohya, B. Andrews, T.R. Hughes, B.J. Frey, T.R. Graham, R.J. Andersen & C. Boone, "Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast," Cell, v. 126, pp. 611-6255 (2006). Download pdf reprint. Examine supplementary data.
63. M. Wojcik, H.F. Seidle, P. Bieganowski & C. Brenner, "Glutamine-Dependent NAD+ synthetase: How a Two-Domain, Three-Substrate Enzyme Avoids Waste," J Biol Chem, v. 281, pp. 33395-33402 (2006). Download pdf reprint
64. P. Belenky, K.L. Bogan & C. Brenner, "NAD+ Metabolism in Health and Disease," Trends in Biochemical Sciences, v. 32, pp. 12-19 (2007). Download pdf reprint
65. C.L. Linster, T.A. Gomez, K.C. Christensen, L.N. Adler, B.D. Young, C. Brenner & S.G. Clarke, "Arabidopis VTC2 Encodes GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants," J Biol Chem, v. 282, pp. 18879-18885 (2007). Download pdf reprint. View or download JBC Paper of the Week Summary.
66. P. Belenky, F.G. Racette, K.L. Bogan, J.M. McClure, J.S. Smith & C. Brenner, "Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+," Cell, v. 129, pp. 473-484 (2007). Download pdf reprint and supplementary data. Read Leading Edge Preview in Cell, Research Highlights in Nature and Spotlight in ACS Chemical Biology.
67. M.E. Robu, J.D. Larson, A. Nasevicius, S. Beiraghi, C. Brenner, S.A. Farber & S.C. Ekker, "p53 Activation by Knockdown Technologies," PLOS Genetics, v. 3, issue 5, e78 (2007). Download pdf reprint.
68. C. Brenner, "Histidine Triad (HIT) Superfamily," Encyclopedia of Life Sciences, (2007), John Wiley & Sons, Ltd: Chichester.
69. W. Tempel, W.M. Rabeh, K.L. Bogan, P. Belenky, M. Wojcik, H.F. Seidle, L. Nedyalkova, T. Yang, A.A. Sauve, H.-W. Park & C. Brenner, "Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD+," PLoS Biology, v. 5, issue 10, e263 (2007). View Nrk1-ADP, Nrk1-NR, Nrk1-AppNHp+NR, Nrk1-NMN, and Nrk1-tiazofurin entries at the Protein Data Bank. Download pdf reprint and supporting information.
70. R.S. Fuller, R.A. Bambara, T. Baker, B. Funnell, E. Wahle, M. O'Donnell, D. Kaiser, K. Skarstad, B. Konforti, S. Maki, T. Katayama, K. Sekimizu, J.H. Weiner, R.W. Davis, L. Rowen, M.F. Goodman, J. Spudich, S. Pfeffer, C.C. Richardson, P. Polaczek, R. Calendar, R. Kolodner, J. Griffith, B. Stillman, P. Modrich, C. Brenner & C. Yanofsky, "A Tribute to Arthur Kornberg, 1918-2007," Nat Struct Mol Biol, v. 15, pp. 2-17 (2008). Download pdf reprint
71. G.L. Loring, K.C. Christensen, S.A. Gerber & C. Brenner, "Yeast Chfr Homologs Retard Cell Cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-Dependent Ubiquitination," Cell Cycle, v. 7, pp. 95-105 (2008). Download pdf reprint and supplementary data
72. P.A. Belenky, T.G. Mogu & C. Brenner, "S. cerevisiae YOR071C Encodes the High Affinity Nicotinamide Riboside Transporter, Nrt1," J Biol Chem, v. 283, pp. 8075-8079 (2008). Download pdf reprint and supplementary data
73. K.L. Bogan & C. Brenner, "Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition," Ann Review Nutrition, v. 28, pp. 115-130 (2008). Download pdf reprint
74. C.L. Linster, L.T. Adler, K. Webb, K.C. Christensen, C. Brenner & S.G. Clarke, "A Second GDP-L-Galactose Phosphorylase in Arabidopsis en Route to Vitamin C: Covalent Intermediate and Substrate Requirements for the Conserved Reaction," J Biol Chem, v. 283, pp. 18483-18492 (2008). Download pdf reprint
75. L. Brooks,III, E.G. Heimsath, Jr., G.L. Loring & C. Brenner, "FHA-RING Ubiquitin Ligases in Cell Division Cycle Control," Cell Mol Life Sci, v. 65, cover and pp. 3458-3466 (2008). Download pdf reprint
76. P. Belenky, K.C. Christensen, F. Gazzaniga, A.A. Pletnev & C. Brenner, "Nicotinamide Riboside and Nicotinic Acid Riboside Salvage in Fungi and Mammals: Quantitative Basis for Urh1 and Purine Nucleoside Phosphorylase Function in NAD+ Metabolism," J Biol Chem, v. 284, pp. 158-164 (2009). Download pdf reprint
77. P. Bieganowski & C. Brenner, "Nicotinamide Riboside Kinase Compositions and Methods for Using the Same,"Australian Patent 2005211773, issued June 1, 2009. 
78. F. Gazzaniga, R. Stebbins, S. Z. Chang, M.A. McPeek & C.Brenner, "Microbial NAD Metabolism: Lessons from Comparative Genomics, "Microbiol Mol Biol Rev, v. 73, pp. 529-541 (2009). Download pdf reprint
79. K.L. Bogan, C. Evans, P. Belenky, P. Song, C.F. Burant, R.T. Kennedy & C. Brenner, " Identification of Isn1 and Sdt1 as Glucose and Vitamin-regulated NMN and NaMN 5'-nucleotidases Responsible for Production of Nicotinamide Riboside and Nicotinic Acid Riboside," J Biol Chem, v. 284, pp. 34861-34869 (2009). Download pdf reprint and supplementary data
80. C. Evans, K.L. Bogan, P. Song, C.F. Burant, R.T. Kennedy & C. Brenner, "NAD+ Metabolite Levels as a Function of Vitamins and Calorie Restriction: Evidence for Different Mechanisms of Longevity," BMC Chem Biol, v. 10, 2 (2010). Download pdf reprint and supplementary data
81. K.L. Bogan & C. Brenner, "5'-Nucleotidases and their New Roles in NAD+ and Phosphate Metabolism," New Journal of Chemistry, v. 34, pp. 845-853 (2010). Download pdf reprint
82. F. Syeda, R.L. Fagan, M. Wean, G.V. Awakumov, J.R. Walker, S. Xue, S. Dhe-Paganon & C. Brenner, "The RFTS Domain is a DNA-Competitive Ingibitor of Dnmt1," JBC, v. 286, pp. 15344-15351 ( 2011). Download pdf reprint
83. C. Brenner. "On the Nonspecific Degradation of NAD+ to Nicotinamide Riboside," JBC, v. 286, p. le5 (2011). Download pdf reprint
84. P. Belenky, R. Stebbins, K.L. Bogan, C.R. Evans & C. Brenner, "Nrt1 and Tna1-Independent Export of NAD+ Precursor Vitamins Promotes NAD+ Homeostasis and Allows Engineering of Vitamin Production," PLoS ONE, v. 6, p. e19710 (2011). Download pdf reprint
85. J. Boylston & C. Brenner, "FHIT," Encyclopedia of Signaling Molecules, S. Choi, ed, chapter 68, part 7, pp. 613-616 (2012). DOI: 10.1007/978-1-4419-0461-4_68. Download pdf reprint
86. C. Brenner, P. Belenky & K.L. Bogan, "Yeast Strain and Method for Using the Same to Produce Nicotinamide Riboside," US Patent 8,114,626, issued February 14, 2012. Download pdf reprint
87. C. Brenner & D. Ringe, "Response to the New MCAT: ASBMB Premedical Curriculum," ASBMB Today, v. 11, pp. 12-14 (2012). Download pdf reprint
88. R.R. Midtkandal, P. Redpath, S.A.J. Trammell, S.J.F. Macdonald, C. Brenner & M.E. Migaud, "Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside," Bioorganic & Medicinal Chemistry Letters v. 22, pp. 5204-7 (2012). Download pdf reprint
89. C. Brenner, "Nicotinamide riboside kinase compositions and methods for using the same," US Patent 8,197,807, issued June 12, 2012. Download pdf reprint
90. C. Brenner, "Changes in Chemistry and Biochemistry Education:  Creative Responses to MCAT Revisions in the Age of the Genome," Biochem and Mol Biol Education, v. 41, pp. 1-4 (2013). Download pdf reprint
91. C. Brenner, "Nicotinamide riboside kinase compositions and methods for using the same," US Patent 8,383,086, issued February 26, 2013. Download pdf reprint
92. K.L. Bogan & C. Brenner, "Biochemistry: Niacin/NAD(P)," Encyclopedia of Biological Chemistry, W.J. Lennarz & M.D. Lane, eds., v. 3, pp.172-178, (2013), Waltham, MA: Academic Press. Download pdf reprint
93. S.A.J. Trammell & C. Brenner, "Targeted, LCMC-Based Metabolomics for Quantitative Measurement of NAD+ Metabolites," Computational and Structural Biotechnology Journal, v. 4, e201301012 (2013). DOI: 10.5936/csbj.201301012. Download pdf reprint.
94. C. Brenner, "Rethinking Premedical and Health Professional Curricula in Light of MCAT 2015," Journal of Chemical Education, v. 90, pp. 807-812 (2013). DOI:10.1021/ed4002738. Download pdf reprint
95. R.L. Fagan, D.E. Cryderman, L. Kopelovich, L.L. Wallrath & C. Brenner, "Laccaic Acid A is a Direct, DNA-Competitive Inhibitor of DNA Methyltransferase 1," J Biol Chem, v.288, pp. 23858-23867 (2013). DOI: 10.1074/jbc.M113.480517. Download pdf reprint.
96. C. Brenner, "Demystifying the Chalk Talk," ASBMB Today, v. 12, number 8, pp. 33-35 (2013). Download pdf reprint
97. S. Ghanta, R.E. Grossmann & C. Brenner, "Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications"  Critical Rev Biochem & Mol Biol, v. 48, pp. 561-574 (2013). Download pdf reprint.
98. P.J. Kennelly, J.S. Bond, B.S. Masters, E.A. Dennis, C. Brenner & D.M. Raben, "Desperately Seeking Flexner: Time to Reemphasize Basic Science in Medical Education" Academic Medicine, v. 88, pp. 1405-1406 (2013). DOI: 10.1097/ACM.0b013e3182a225be. Download pdf reprint
99. R.L. Fagan, M. Wu, F. Chédin & C. Brenner, "An Ultrasensitive High Throughput Screen for DNA Methyltransferase 1-targeted Molecular Probes" PLoS One, v. 11,e78752 (2013). Download pdf reprint.
100. S-C. Mei & C. Brenner, “NAD as a Genotype-Specific Drug Target” Chemistry & Biology, v. 20, pp. 1307-1308 (2013). Download pdf reprint
101.  J. Huang, A. Stewart, B. Maity, J. Hagen, R.L. Fagan, J. Yang, D.E. Quelle, C. Brenner & R.A. Fisher, "RGS6 Suppresses Ras-inducded Cellular Transformation by Facilitating Tip60-mediated Dnmt1 Degradation and Promoting Apoptosis,"Oncogene, v. 33, pp. 3604-11 (2014). DOI:10.1038/onc.2013.324. Download pdf reprint
102.  C. Brenner, “Understanding Faculty Salaries,” ASBMB Today, v. 13, number 1, pp. 28-29 (2014). Download pdf reprint
103.  C. Brenner, “Metabolism: Targeting a fat-accumulation gene” Nature, v. 508, pp. 194-195 (2014). DOI: 10.1038/508194a. Download pdf reprint.
104. C. Brenner, "Histidine Triad Superfamily" Encyclopedia of Life Sciences, John Wiley & Sons Ltd: Chichester (2014).  DOI: 10.1002/9780470015902.a0020545.pub2.
105. J.A. Boylston & C. Brenner, "A Knockdown with Smoke Model Reveals Fhit as a Repressor of Heme Oxygenase 1," Cell Cycle, v. 13, pp. 2913-30 (2014). DOI:10.4161/15384101.2014.946858. Download pdf reprint
106. B.-K. Wu, S.-C. Mei & C. Brenner, "RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation," Cell Cycle, v. 13, pp. 3222-3231 (2014). DOI:10.4161/15384101.2014.950886. Download pdf reprint
107. S.-C. Mei & C. Brenner, "Quantification of Protein Copy Number in Yeast: the NAD+ Metabolome," PLoS One v. 9, e106496 (2014). DOI: 10.1371/journal.pone.0106496. Download pdf reprint
108. B.-K. Wu & C. Brenner, “Suppression of TET1-Dependent DNA Demethylation is Essential for KRAS-Mediated Transformation,” Cell Reports, v. 9, pp. 1827-1840 (2014). DOI:10.1016/j.celrep.2014.10.063. Download pdf reprint
109. C. Brenner, “Boosting NAD to Spare Hearing,” Cell Metabolism, v. 21, pp.926-927 (2014). DOI: 10.1016/j.cmet.2014.11.015. Download pdf reprint.
110.  S.-C. Mei & C. Brenner, "Calorie Restriction-Mediated Replicative Lifespan Extension in Yeast Is Non-Cell Autonomous," PLoS Biology, v. 13, e1002048 (2015). Download pdf reprint
111. S.A.J. Trammell & C. Brenner, “NNMT: A Bad Actor in Fat Makes Good in Liver,” Cell Metabolism, v. 22, pp. 200-201 (2015). DOI:10.1016/j.cmet.2015.07.017. Download pdf reprint
112. S.A.J. Trammell, L. Yu, P. Redpath, M.E. Migaud & C. Brenner, "Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk," The Journal of Nutrition, v. 146, pp. 957-963 (2016). DOI: 10.3945/jn.116.230078. Download pdf reprint
113. S.A.J. Trammell, B.J.Weidemann, A.Chadda, M.S. Yorek, A. Holmes, L.J.Coppey, A. Obrosov, R.H. Kardon, M.A. Yorek & C. Brenner, “Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice,” Scientific Reports, v. 6, 26933 (2016). DOI: 10.1038/srep26933. Download pdf reprint
114. S.A.J Trammell, M.S. Schmidt, B.J. Weidemann, P. Redpath, F. Jaksch, R.W. Dellinger, Z. Li, E.D. Abel, M.E. Migaud & C. Brenner, "Nicotinamide riboside is uniquely and orally bioavailable in mice and humans." Nat Commun. v. 7, pp. 12948 (2016). DOI: 10.1038/ncomms12948. Download pdf reprint
115. J. Ratajczak, M. Joffraud, S.A.J. Trammell, R. Ras, N. Canela, M. Boutant, S.S. Kulkarni, M. Rodrigues, P. Redpath, M.E. Migaud, J. Auwerx, O. Yanes, C. Brenner & C. Canto, "NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells." Nat Commun. v. 7, pp. 13103 (2016). DOI: 10.1038/ncomms13103. Download pdf reprint.
116. J.L. Wilsbacher, M. Cheng, D. Cheng, S.A.J. Trammell, Y. Shi, J. Guo, S.L. Koeniger, P.J. Kovar, Y. He, S. Jagadeeswaran, H.R. Heyman, B.K. Sorensen, R.F. Clark, T.M. Hansen, K.L. Longenecker, D. Raich,  A.V. Korepanova, D.L. Towne, V.C. Abraham, H. Tang, S.M. McLoughlin, M.L. Curtin, M.R. Michaelides, D. Maag, F.G. Buchanan, W. Gao, S.H. Rosenberg, C. Brenner & C. Tse, “Discovery and Characterization of Novel, Orally Bioavailable Non-substrate and Substrate NAMPT Inhibitors,” Molecular Cancer Therapeutics, v. 16, pp. 1236-1245 (2017). DOI:10.1158/1535-7163.MCT-16-0819. Download PDF reprint.
117. M.V. Hamity, S.R. White, R.Y. Walder, M.S. Schmidt, C. Brenner & D.L. Hammond, “Nicotinamide Riboside, a Form of Vitamin B3 and NAD+ Precursor, Relieves the Nociceptive and Aversive Dimensions of Paclitaxel-induced Peripheral Neuropathy in Female Rats,” Pain, v. 158, pp. 962–972 (2017). DOI:10.1097/j.pain.0000000000000862. Download PDF reprint.
118. R. Fletcher, J. Ratajczak, C.L. Doig, L.A. Oakey, R.Callingham, G. da Silva Xavier, A. Garten, Y.S. Elhassan, P. Redpath, M.E. Migaud, A. Philp, C. Brenner, C. Canto & G.G. Lavery, “Nicotinamide Riboside Kinases Display Redundancy in Mediating Nicotinamide Mononucleotide and Nicotinamide Riboside Metabolism in Skeletal Muscle Cells," Molecular Metabolism, v. 6 (2017). DOI: 10.1016/j.molmet.2017.05.011. Download PDF reprint.
119. P. Vaur, B. Brugg, M. Mericskay, Z. Li, M.S. Schmidt, D. Vivien, C. Orset, E. Jacotot, C. Brenner & E. Duplus, “Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration,” FASEB Journal (2017). DOI: 10.1096/fj.201700221RR. Download PDF reprint.
120. S.Thakur & C. Brenner, “KRAS-driven miR-29b Expression is Required for Tumor Suppressor Gene Silencing,” Oncotarget, v.8(43), pp. 74755-74766 (2017). DOI: 10.18632/oncotarget.20364. Download PDF reprint.
121. S. Sato, G. Solanas, F.O. Peixoto, L. Bee, A. Symeonidi, M.S. Schmidt, C. Brenner, S. Masri, S.A. Benitah &  P. Sassone-Corsi, “Circadian Reprogramming Identifies Metabolic Pathways of Aging,” Cell, v. 170(4), pp. 664-677 (2017). DOI: 10.1016/j.cell.2017.07.042. Download PDF reprint.
122. N. Diguet, S.A.J. Trammell, C. Tannous, R. Deloux, J. Piquereau, N. Mougenot, A. Gouge, M. Gressette, B. Manoury, J. Blanc, M. Breton, J.F. Decaux, G. Lavery, I. Baczkó, J. Zoll, A. Garnier, Z. Li, C. Brenner & M. Mericskay, "Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy," Circulation, v. 137(21), pp. 2256-2273 (2018). DOI: 10.1161/CIRCULATIONAHA.116.026099. Download PDF reprint. Read accompanying commentary.
123. D. Fangmann, E.M. Theismann, K. Türk, D.M. Schulte, I. Relling, K. Hartmann, J.K. Keppler, J.R. Knipp, A. Rehman, F.A. Heinsen, A. Franke, L. Lenk, S. Freitag-Wolf, E. Appel, S. Gorb, C. Brenner, D. Seegert, G.H. Waetzig, P. Rosenstiel, S. Schreiber, K. Schwarz & M. Laudes, "Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans," Diabetes Care, v. 41(3), pp. 398-405 (2018). DOI: 10.2337/dc17-1967. Download PDF reprint.
124. D.S. Matasic, C. Brenner & B. London, "Emerging Potential Benefits of Modulating NAD+ Metabolism in Cardiovascular Disease," Am J Physiol Heart Circ Physiol, v. 314(4), pp. H839-H852 (2018). DOI: 10.1152/ajpheart.00409.2017. Download PDF reprint.
125. O.L. Dollerup, B.Christensen, M. Svart, M.S. Schmidt, K. Sulek, S. Ringgaard, H. Stødkilde-Jørgensen, N. Møller, C. Brenner, J.T. Treebak &N. Jessen, "A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects," Am J Clin Nutr., v.108(2), pp. 343-353 (2018). DOI: 10.1093/ajcn/nqy132.  Download PDF reprint.
126. S.J. Mitchell, M. Bernier, M.A. Aon, S. Cortassa, E.Y. Kim, E.F. Fang, H.H. Palacios, Ali A1, I. Navas-Enamorado, A. Di Francesco, T.A. Kaiser, T.B. Waltz, N. Zhang, J.L. Ellis, P.J. Elliott, D.W. Frederick, V.A. Bohr, M. S. Schmidt, C. Brenner, D.A. Sinclair, A. A. Sauve, J.A. Baur & R. de Cabo, "Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice," Cell Metab. 27(3):667-676.e4 (2018). DOI: 10.1016/j.cmet.2018.02.001. Download PDF reprint.
127. H.W. Liu, C.B. Smith, M.S. Schmidt, X.A. Cambronne, M.S. Cohen, M.E. Migaud, C. Brenner & R.H. Goodman, "Pharmacological bypass of NAD+ salvage pathway protects neurons from chemotherapy-induced degeneration," Proc Natl Acad Sci U S A. v.115 (42), pp.10654-10659 (2018). DOI: 10.1073/pnas.1809392115. Download PDF reprint
128. C. Brenner & A.C. Boileau, "Pterostilbene Raises Low Density Lipoprotein Cholesterol in People," Clinical Nutrition. v.38(1), pp.480-481 (2019), DOI:10.1016/j.clnu.2018.10.007. Download PDFreprint.
129. P. H. Ear, A. Chadda, S. B. Gumusoglu, M. S. Schmidt, S. Vogeler, J. Malicoat, J. Kadel, M. M. Moore, M. E. Migaud, H. E. Stevens & C. Brenner, "Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring," Cell Reports. v. 26 (4), pp. 969-983 (2019). DOI: 10.1016/j.celrep.2019.01.007. Download PDFreprint.
130. W. Shi, M.A. Hegeman, A. Doncheva, I. van der Stelt, M. Bekkenkamp-Grovenstein, E. M. van Schothorst, C.Brenner, V. C. J. de Boer & J. Keijer, "Transcriptional Response of White Adipose Tissue to Withdrawal of Vitamin B3," Mol Nutr Food Res., v. 2019. DOI: 10.1002/mnfr.201801100. Dowload PDFreprint
131. D. Conze,  C. Brenner, & C.L. Kruger, "Safety and Metabolism of Long-Term Administration of Niagen (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults," Scientific Reports, v. 9, 9772, 2019. DOI: 10.1038/s41598-019-46120-z. Download PDF reprint
132. M.S. Schmidt, & C. Brenner, "Absence of evidence that Slc12a8 Encodes a Nicotinamide Mononucleotide Transporter," Nature Metabolism, v. 1, pp. 660-661 (2019). DOI: 10.1038/s42255-019-0085-0. Download PDFreprint
133. Y.S. Elhassan, K. Kluckova, R.S. Fletcher, M.S. Schmidt, A. Garten, C.L. Doig, D.M. Cartwright, L. Oakey, C.V. Burley, N Jenkinson, M. Wilson, S.J.E. Lucas, I. Akerman, A. Seabright, Y.C. Lai, D.A. Tennant, P. Nightingale, G.A. Wallis, K.N. Manolopoulos, C. Brenner, A. Philip, G.G. Lavery, "Nicotinamide Riboside Augments the Human Skeletal Muscle NAD Metabolome and Induces Transcriptomic ad Anti-inflammatory Signatures in Aged Subjects: a Placebo-controlled, Randomized Trial," Cell Reports, v. 28, 7 2019. DOI: 10.1016/j.celrep.2019.07.043. Download PDFreprint 
134. C. Brenner, "Why Is Mom Stressed: Homeorhesis as the Potential Problem and Nicotinamide Riboside as the Potential Solution," Journal of Experimental Neuroscience v. 13, pp. 1-3  (2019). DOI: 10.1177/1179069519869679. Download PDF reprint
135. N.R. Fons, R.K. Sundaram, G.A. Breuer, S. Peng, R.L. McLean, A.N. Kalathil, M.S. Schmidt, D.M. Carvalho, A. Mackay, C. Jones, A.M. Carcaboso, J. Nazarian, M.E. Berens, C. Brenner, & R.S. Bindra., "PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma," Nature Communications, v. 10, 3790 (2019). DOI: 10.1038/s41467-019-11732-6. Download PDF reprint
136. D.S. Matasic, J-T. Yoon, H. Mehdi, J.M. McLendon, M.S. Schmidt, A.M. Greiner, P. Quinones, G.M. Morgan, R. Bourdreau, K. Irani, C. Brenner & B. London., "Modulation of the Cardiac Sodium Channel Nav1.5 Peak and Late Currents by NAD⁺ Precursors," Journal of Molecular and Cellular Cardiology., J Mol Cell Cardiol v. 141, pp. 70-81, (2020) DOI: 10.1016/j.yjmcc.2020.01.013 Download PDF reprint
137. E. Pirinen, M. Auranen, N. Khan, V. Brilhante, N. Urho, A. Pessia, A. Hakkarainen, J. Kuula, U. Heinonen, M.S. Schmidt, K. Haimilahti, P. Piirila, N. Lundbom, M.R. Taskinen, C. Brenner, V. Velagapudi, K. Pietilainen, A. Suomalainen, "Niacin Cures Systematic NAD⁺ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy," Cell Metabolism, May 2020. DOI: 10.1016/j.cmet.2020.04.008 Download PDF reprint
138. D.C. Levine, H. Hong, K.M. Ramsey, A.H. Affinati, M.S. Schmidt, J. Cedernaes, C. Omura, C. Lee, C. Brenner, C.B. Peek & J. Bass. "NAD⁺ Controls Circadian Reprogramming Through PER2 Nuclear Translocation to Counter Aging," Molecular Cell May, 2020. https://doi.org/10.1016/j.molcel.2020.04.010 Download PDF reprint
139. N.T. Fluharty, C. Brenner, "Fat Mobilization Without Weight Loss is a Potentially Rapid Response to Nicotinamide Riboside in Obese People: It's Time to Test with Exercise," American Journal of Clinical Nutrition, May, 2020. DOI: 10.1093/ajcn/nqaa109 Download PDF reprint
140. C.D. Heer, C. Brenner, "Letting off Electrons to Cope with Metabolic Stress," Nature Metabolism, May 2020 DOI: 10.1038/s42255-020-0207-8 Download PDF reprint
141. R. Parker, M.S. Schmidt, O. Cain, B. Gunson & C. Brenner., "The NAD⁺ Metabolome is Functionally Depressed in Patients Undergoing Liver Transplantation for Alcohol-related Liver Disease," Hepatology Communications, May 2020 DOI: 10.1002/hep4.1530 Download PDF reprint
142. M. Gerasimenko, S. Cherepanov, K. Furuhara, O. Lopatina, A. Salmina, A. Shabalova, C. Tsuji, S. Yokoyama, K. Ishihara, C. Brenner, H. Higashida, "Nicotinamide Riboside Supplementation Corrects the Deficits in Oxytocin, Sociability and Anxiety of CD157 Mutants in a Mouse Model of Autism Spectrum Disorder," Scientific Reports, June 2020. DOI: 10.1038/s4198-029-57236-7 Download PDF reprint
143. A.J. Covarrubias, J. A. Lopez-Dominguez, R. Perrone, A. Kale, J. Newman, S. S. Iyer, M. S. Schmidt, H. G. Kasler, K.-O. Shin, Y.-M. Lee, I. Ben-Sahra, M. Ott, C. Brenner, J.Campisi & E. Verdin, "Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages," in review. DOI: 10.1101/609438. Download PDF preprint
144. C.D. Heer, D.J. Sanderson, Y.M.O. Alhammad, S.A. J. Trammell, M.S. Schmidt, S. Perlman, M.S. Cohen, A.R. Fehr, C. Brenner, "Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity," in review. DOI: 10.1101/2020.04.17.047480 Download PDF preprint
145. B.C. Gilmour, R. Gudmundsrud, J. Frank, A.Hov, S.H.Lautrup, Y. Aman, H. Røsjø, C. Brenner, M. Ziegler, O.-B. Tysnes, C. Tzoulis, T. Omland, A. Søraas, T. Holmøy, L.H. Bergersen, J. Storm-Mathisen, H. Nilsen, E.F. Fang, "Targeting NAD⁺ in translational research to relieve diseases and conditions of metabolic stress and ageing," Mechanisms of Ageing and Development v. 186, March 2020 DOI 10.1016/j.mad.2020.111208 Download PDF reprint
146. T.S. Nam, D.R. Park, S.-Y. Rah, T.G. Woo, H.T. Chung, C. Brenner, U.-H. Kim. "IL8 Drives an Elaborate Signal Transduction Process for CD38 to Produce NAADP from NAAD and NADP⁺ in Endolysosomes to Effect Cell Migration," in review DOI: 10.1101/2020.03.24.004739 Download PDF preprint

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