Curriculum Vitae

Charles Brenner, PhD

Roy J. Carver Chair of Biochemistry and Professor of Internal Medicine
Founding Co-Director of the University of Iowa Obesity Research and Education Initiative

Carver College of Medicine
University of Iowa
51 Newton Road
4-403 Bowen Science Building (BSB)
Iowa City, IA 52242

Office Phone: (319) 335-7934
Lab Phone: (319) 384-4099
Email: charles-brenner@uiowa.edu

Education

Undergraduate

Graduate

Post-doctoral

Honors and Awards

  • 1979-1980 Connecticut State Scholar
  • 1979-1983 National Merit Scholar
  • 1988-1992 Program in Cancer Biology trainee of the NCI
  • 1993-1996 Fellow of the Leukemia Society of America
  • 1994 Leukemia Society of America Short-Term Scientific Exchange Award
  • 1997-present National Cancer Institute, CA075954, Functional and Structural Analysis of HIT Proteins/ Mechanism of Dnmtl Up-regulation by Fhit Loss
  • 1998-2000 Basil O'Connor Scholar of the March of Dimes Birth Defects Foundation
  • 1998-2000 Beckman Young Investigator of the Arnold and Mabel Beckman Foundation
  • 1998-2001 Burroughs Wellcome Fund New Investigator in the Basic Pharmacological Sciences
  • 2007 William E.M. Lands Lecturer in Nutritional Biochemistry, University of Michigan
  • 2007-present National Institute of General Medical Sciences, GM081665, Quantitative Analysis of RING E3 Ubiquitin Ligases
  • 2008-2011 National Science Foundation, MCB-0822581, New Steps in NAD+ Metabolism
  • 2008-2009 Lung Cancer Research Foundation Award
  • 2010- present Roy J. Carver Chair of Biochemistry
  • 2012 Holden Comprehensive Cancer Center Oberley Award
  • 2013 Fellow of the American Association for the Advancement of Science
  • 2013-2014 National Science Foundation, MCB-1322118, EAGER: Discovery of an Extracellular Mediator of Glucose Restriction in Yeast
  • 2014 State of Iowa Regents Award for Faculty Excellence
  • 2014-present National Science Foundation, CHE-1404147, Chemistry of Mitochondrial Protein Acetylation: Evolution of Substrate Reactivity as a Regulatory Mechanism
  • 2014-present National Institute of Alcohol Abuse and Alcoholism, AA022371 Role of Mitochondrial Protein Acetylation in the Liver Pathology of Alcohol
  • 2015 Ackerson Student Lecturer in Biochemistry & Redox Biology, University of Nebraska
  • 2015 Keynote Lecturer at the Brown University Pathobiology Retreat
  • 2016 ASBMB Award for Exemplary Contributions to Education

National Service

  • 1998 Organizer of Wesleyan University Alumni Symposium on Biology and the New Pharmacopaeia
  • 2004-2007 F04B, Biophysical and Biochemical Sciences Fellowship Study Section, National Institutes of Health
  • 2004 Structural Biology Program, Department of Energy
  • 2005-2007 Beckman Young Investigator Review Committee, Arnold and Mabel Beckman Foundation
  • 2008 American Federation for Aging Research National Scientific Advisory Council
  • 2008-present ICP1, International Cooperative Projects Study Section, National Institutes of Health
  • 2009-2012 ASBMB Publications Committee (chair, 2011-2012)
  • 2012-present ASBMB representative to AAMC Council of Academic Societies 

Professional Experience

  • 1983-1985 Research Associate for Anthony J. Brake
    Chiron Corporation, Emeryville, CA
  • 1986-1988 Research Associate for Kunihiro Matsumoto
    DNAX Research Institute, Palo Alto, CA
  • 1996-2000 Assistant Professor of Microbiology & Immunology
    Jefferson Medical College
    Member, Program in Structural Biology, Kimmel Cancer Center
  • 2000-2003 Associate Professor of Microbiology & Immunology
    Jefferson Medical College
    Director, Structural Biology & Bioinformatics Program, Kimmel Cancer Center
    Thomas Jefferson University, Philadelphia, PA
  • 2003-2007 Associate Professor of Genetics and of Biochemistry
    Dartmouth Medical School
  • 2003-2008 Director, Cancer Mechanisms Program
    Norris Cotton Cancer Center
  • 2005-2009 Scientific Director
    Comprehensive Thoracic Oncology Program
    Dartmouth-Hitchcock Medical Center
  • 2007-2009 Professor of Genetics and of Biochemistry
    Dartmouth Medical School
  • 2008-2009 Associate Director for Basic Sciences
    Norris Cotton Cancer Center, Lebanon, NH
  • 2009-present Professor and DEO of Biochemistry
    Carver College of Medicine
    University of Iowa, Iowa City, IA
  • 2010-present Professor of Internal Medicine and Roy J. Carver Chair in Biochemistry
    Carver College of Medicine
    University of Iowa, Iowa City, IA
  • 2011-present Founding Co-Director, Obesity Research and Education Initiative
    Office of the Provost
    University of Iowa, Iowa City, IA

Teaching

  • 1997-2003 Yeast Transformation section of BI532
  • 1997-2003 X-ray Crystallography section of PR613 including the Difference Patterson Function
  • 1999-2003 Yeast Genetics section of GE611
  • 1999-2003 Yeast Cell Cycle and Cell Cycle Checkpoints section of GE636
  • 2004-2009 NAD+ Metabolism section of the MCB Core Course
  • 2005-2008 Genetics 144, Oncogenomics
  • 2005-2007 Yeast Genetics section of the MCB Core Course
  • 2010-Present Carbohydrate Metabolism Section of BIOC:3120

Editorial

Professional Societies

Publications

  1. A. Brake, C. Brenner, R. Najarian, P. Laybourn & J. Merryweather, "Structure of Genes Encoding Precursors of the Yeast Peptide Mating Pheromone a-Factor" in Protein Transport and Secretion, M. J. Gething, ed., pp. 103-108 (1985). Download pdf PDF iconreprint
  2. I. Miyajima, M. Nakafuku, N. Nakayama, C. Brenner, A. Miyajima, K. Kaibuchi, K. Arai, Y. Kaziro & K. Matsumoto, "GPA1, A Haploid-Specific Essential Gene, Encodes a Yeast Homolog of Mammalian G Protein Which May Be Involved in Mating Factor Signal Transduction," Cell, v. 50, pp. 1011-1019 (1987). Download pdf PDF iconreprint
  3. C. Brenner, N. Nakayama, M. Goebl, K. Tanaka, A. Toh-e & K. Matsumoto, "CDC33 Encodes mRNA Cap-Binding Protein eIF-4E of Saccharomyces cerevisiae," Mol Cell Biol, v. 8, pp. 3556-3559 (1988). Download pdf PDF iconreprint
  4. K. Matsumoto, M. Nakafuku, N. Nakayama, I. Miyajima, K. Kaibuchi, A. Miyajima, C. Brenner, K. Arai & Y. Kaziro, "The Role of G Proteins in Yeast Signal Transduction," Cold Spring Harbor Symp Quant Biol, v. 53, pp. 567-575 (1988). Download pdf PDF iconreprint
  5. R.S. Fuller, C. Brenner, P. Gluschankof & C.A. Wilcox, "The Yeast Prohormone-Processing Kex2 Protease, an Enzyme with Specificity for Paired Basic Residues," in Methods in Protein Sequence Analysis, Jornvall, H., Hoog, J.-O. & Gustavsson, A.-M., pp. 205-214 (1991). Download pdf PDF iconreprint
  6. C. Brenner & R.S. Fuller, "Structural and Enzymatic Characterization of a Purified Prohormone-Processing Enzyme: Secreted, Soluble Kex2 Protease," Proc Natl Acad Sci, v. 89, pp. 922-926 (1992). Download pdf PDF iconreprint
  7. H. Angliker, P. Wikstrom, E. Shaw, C. Brenner & R.S. Fuller, "The Synthesis of Inhibitors of Processing Proteases and Their Action on the Kex2 Protease of Yeast," Biochem J, v. 293, pp. 75-81 (1993). Download pdf PDF iconreprint
  8. C. Brenner, A. Bevan & R.S. Fuller, "One-Step Site-Directed Mutagenesis of The Kex2 Protease Oxyanion Hole,"Current Biology, v. 3, pp. 498-506 (1993). Download pdf PDF iconreprint
  9. C. Brenner, A. Bevan & R. S. Fuller, "Methods for Analyzing the Specificity and Activity of a Prohormone-Processing Enzyme, the Yeast Kex2 Protease (Kexin)," Meth Enz, v. 244, pp. 152-167 (1994). Download pdf PDF iconreprint
  10. C. Brenner, "Reducing the Energy Barrier to Crystallization, review of Crystallization of Nucleic Acids and Proteins,"Protein Science, v. 3, pp. 2471-2472 (1994). Download pdf PDF iconreprint
  11. H. Diefenbach-Jagger, C. Brenner, B.E. Kemp, W. Baron, J. McLean, T.J. Martin & J.M. Moseley, "Arg21 is the Preferred Kexin Cleavage Site in Parathyroid-Hormone-Related Protein," Eur J Biochem, v. 229, pp. 91-98 (1995). Download pdf PDF iconreprint
  12. C. Brenner, P. Garrison, J. Gilmour, D. Peisach, D. Ringe, G.A. Petsko & J.M. Lowenstein, "Crystal Structures of Hint Demonstrate that Histidine Triad Proteins are GalT-related Nucleotide-Binding Proteins," Nature Structural Biology, v. 4, pp. 231-238 (1997). View Hint-GMPHint-AdenosineHint-8-Br-AMPApo-Hint entries at the Protein Data Bank. Download pdf PDF iconreprint
  13. C. Brenner, H.C. Pace, P.N. Garrison, A.K. Robinson, A. Rosler, X.H. Liu, G.M. Blackburn, C.M. Croce, K. Huebner & L.D. Barnes, "Purification and Crystallization of Complexes Modeling the Active State of the Fragile Histidine Triad Protein," Protein Engineering, v. 10, pp. 1461-1463 (1997). Download pdf PDF iconreprint
  14. G.M. Blackburn, X. Liu, A. Rosler & C. Brenner, "Two Hydrolase Resistant Analogues of Diadenosine 5',5'''-P1,P3-triphosphate for Studies with Fhit, the Human Fragile Histidine Triad Protein," Nucleosides and Nucleotides, v. 17, pp. 301-308 (1998). Download pdf PDF iconreprint
  15. H.C. Pace, P.N. Garrison, A.K. Robinson, L.D. Barnes, A. Draganescu, A. Rosler, G.M. Blackburn, Z. Siprashvili, C.M. Croce, K. Huebner & C. Brenner, "Genetic, Biochemical and Crystallographic Characterization of Fhit-Substrate Complexes as the Active Signaling Form of Fhit," Proc Natl Acad Sci, v. 95, pp. 5484-5489 (1998). View Fhit-IB2Fhit H96N-IB2 entries at the Protein Data Bank. Download pdf PDF iconreprint
  16. Y. Pekarsky, M. Campiglio, Z. Siprashvili, T. Druck, Y. Sedkov, S. Tillib, A. Draganescu, P. Wermuth, J.H. Rothman, K. Huebner, A.M. Buchberg, A. Mazo, C. Brenner & C.M. Croce, "Nitrilase and Fhit Homologs are Encoded as Fusion Proteins in Drosophila melanogaster and Caenorhabditis elegans," Proc Natl Acad Sci, v. 95, pp. 8744-8749 (1998). Download pdf PDF iconreprint
  17. A. Bevan, C. Brenner & R.S. Fuller, "Quantitative Assessment of Enzyme Specificity in vivo: PRecognition by Kex2 Protease Defined in a Genetic System," Proc Natl Acad Sci, v. 95, pp. 10384-10389 (1998). Download pdf PDF iconreprint
  18. X. Liu, C. Brenner, A. Guranowski, E. Starzynska & G.M. Blackburn, "New Tripodal, 'Supercharged Analogs' of Adenosine Nucleotides: Inhibitors for the Fhit Ap3A Hydrolase," Angew Chem Int Ed, v. 38, pp. 1244-1247 (1999). Download pdf PDF iconreprint(set printer for A4 layout and/or "Shrink To Fit").
  19. C. Brenner, "Fhit-Substrate Complexes: A New Paradigm in Reversible Protein Phosphorylation," Proceedings of theXIVth International Conference on Phosphate Chemistry, Phosphorus, Sulfur and Silicon, v. 144-146, pp. 745-748 (1999). Download pdf PDF iconreprint
  20. K. Huebner, G. Sozzi, C. Brenner, M.A. Pierotti & C.M. Croce, "Fhit Loss in Lung Cancer: Diagnostic and Therapeutic Implications," Advances in Oncology, v. 15, pp. 3-10 (1999). Download pdf PDF iconhuebner99(9.2 MB file).
  21. M.J. Fernandes, A.A. Finnegan, L.D. Siracusa, C. Brenner, N.N. Iscove & B. Calabretta, "Characterization of a Novel Receptor that Maps Near the Natural Killer Gene Complex: Demonstration of Carbohydrate Binding and Expression in Hematopoietic Cells," Cancer Research, v. 59, pp. 2709-2717 (1999). Download pdf PDF iconreprint
  22. C. Brenner, P. Bieganowski, H.C. Pace & K. Huebner, "The Histidine Triad Superfamily of Nucleotide-Binding Proteins," J Cellular Physiology, v. 181, pp. 179-187 (1999). Download pdf PDF icon<img alt="PDF icon" class="file-icon" src="https://brenner.lab.uiowa.edu/modules/file/icons/application-pdf.png" title="application/pdf">reprint. Please see ref. 38 for the most current review on HIT proteins.
  23. A. Draganescu, S.C. Hodawadekar, K.R. Gee & C. Brenner, "Fhit-Nucleotide Specificity Probed with Novel Fluorescent and Fluorogenic Substrates," J Biol Chem, v. 275, pp. 4555-4560 (2000). Download pdf PDF iconreprint The reagents can be ordered from Molecular Probes, Inc.
  24. C. Brenner, "A Cultivated Taste for Yeast," Genome Biology, v. 1, pp. reviews103.1-103.4 (2000). Download pdf PDF iconreprint
  25. C. Brenner, "Fhitness and Cancer in the Mouse," Trends in Genetics, v. 16, p. 294 (2000). Download pdf PDF iconreprint
  26. H.C. Pace, S.C. Hodawadekar, A. Draganescu, J. Huang, P. Bieganowski, Y. Pekarsky, C.M. Croce & C. Brenner, "Crystal Structure of the Worm NitFhit Rosetta Stone Protein Reveals a Nit Tetramer Binding Two Fhit Dimers," Current Biology, v. 10, pp. 607-617 (2000). View NitFhit at the Protein Data Bank. Download pdf PDF iconreprint
  27. C. Brenner, "Condensing the RNA World," Trends in Biochemical Sciences, v. 25, p. 485 (2000). Download pdf PDF iconreprint
  28. J.R. Boyne, H.M. Yosuf, P. Bieganowski, C. Brenner & C. Price, "Yeast Myosin Light Chain, Mlc1p, Interacts with Both IQGAP and Class II Myosin to Effect Cytokinesis," J Cell Science, v. 113, pp. 4533-4543 (2000). Download pdf PDF iconreprint
  29. H.C. Pace & C. Brenner, "The Nitrilase Superfamily: Classification, Structure and Function," Genome Biology, v. 2, pp. reviews0001.1-0001.9 (2001). Download pdf PDF icon<img alt="PDF icon" class="file-icon" src="https://brenner.lab.uiowa.edu/modules/file/icons/application-pdf.png" title="application/pdf">reprint. See supplemental data file at Genome Biology.
  30. L. Daheron, T. Zenz, L.D. Siracusa, C. Brenner & B. Calabretta, " Molecular Cloning of Ian4: a BCR/ABL-Induced Gene that Encodes an Outer Membrane Mitochondrial Protein with GTP-Binding Activity, " Nucleic Acids Research, v. 29, pp. 1308-1316 (2001). Download pdf PDF iconreprint
  31. A.G. McLennan, L.D. Barnes, G.M. Blackburn, C. Brenner, A. Guranowski, A.D. Miller, J.M. Rovira, P. Rotllan, B. Soria, J.A. Tanner & A. Sillero, "Recent Developments in the Study of the Intracellular Function of Diadenosine Polyphosphates," Drug Development Research, v. 52, pp. 249-259 (2001). Download pdf PDF iconreprint
  32. J.M. Varnum, J. Baraniak, R. Kaczmarek, W.J. Stec & C. Brenner, "Di-, Tri- and Tetra-5-O-Phosphorothioadenosyl Substituted Polyols as Inhibitors of Fhit: Importance of the Alpha-Beta Bridging Oxygen and Beta Phosphorus Replacement, " BMC Chemical Biology, v. 1, 3 (2001). Download pdf PDF iconreprint
  33. C. Brenner, "FHIT" in the Wiley Encyclopedia of Molecular Medicine, v. 2, Thomas E. Creighton, Ed., pp. 1274-1275 (2001). Download pdf PDF iconreprint
  34. D.H. Klaubert, K.R. Gee & C.M. Brenner, "Phosphate-Bound Polyazaindacene Derivatives of Nucleotides," US Patent 6,323,186, issued November 27, 2001. Download pdfPDF iconreprint
  35. S.K. Milano, H.C. Pace, Y.-M. Kim, C. Brenner & J. Benovic, "Scaffolding Functions of Arrestin-2 Revealed by Crystal Structure and Mutagenesis," Biochemistry, v. 41, pp. 3321-3328 (2002). View Arrestin-2 at the Protein Data Bank. Download pdf PDF iconreprint
  36. P. Bieganowski, P.N. Garrison, S.C. Hodawadekar, G. Faye, L.D. Barnes & C. Brenner, "Adenosine Monophosphoramidase Activity of Hint and Hnt1 Supports Function of Kin28, Ccl1 and Tfb3, " J Biol Chem, v. 277, pp. 10852-10860 (2002). Download pdf PDF iconreprint
  37. M. Rubio-Texeira, J.M. Varnum, P. Bieganowski & C. Brenner, "Control of Dinucleoside Polyphosphates by the FHIT-Homologous HNT2 Gene, Adenine Biosynthesis, and Heat Shock in Saccharomyces cerevisiae," BMC Molecular Biology, v. 3, 7 (2002). Download pdf PDF iconrubio-texeira02
  38. C. Brenner, "Hint, Fhit and GalT: Function, Structure, Evolution and Mechanism of Three Branches of the Histidine Triad Superfamily of Nucleotide Hydrolases and Transferases," Biochemistry, v. 41, pp. 9003-9014 (2002). Download pdf PDF iconreprint
  39. C. Brenner, "Catalysis in the Nitrilase Superfamily," Current Opinion in Structural Biology, v. 6, pp. 775-782 (2002). Download pdf PDF iconreprint
  40. A. Owczarek, R. Kaczmarek, B. Mikolajczyk, E. Wasilewska, D. Korczynski, J. Baraniak, M. Koziolkiewicz, W.J. Stec WJ & C. Brenner, "Stereochemical analysis of diastereomeric 1,3-bis(adenosine-5'-O-phosphorothioyl)glycerols,"Nucleosides, Nucleotides and Nucleic Acids, v. 22, pp. 797-9 (2003).
  41. F. Trapasso, A. Krakowiak, R. Cesari, J. Arkles, S. Yendamuri, H. Ishii, A. Vecchione, T. Kuroki, P. Bieganowski, H.C. Pace, K. Huebner, C.M. Croce & C. Brenner, "Designed FHIT Alleles Establish that Fhit-Induced Apoptosis in Cancer Cells is Limited by Substrate-Binding," Proc Natl Acad Sci, v. 100, pp. 1592-1597 (2003). Download pdf PDF iconreprint
  42. H.C. Pace & C. Brenner, "Feminizing Chicks: A Model for Avian Sex Determination Based on Titration of Hint Enzyme Activity and the Predicted Structure of an Asw-Hint Heterodimer," Genome Biology, v. 4, R18 (2003). Download pdf PDF iconreprint
  43. P. Bieganowski, H.C. Pace & C. Brenner, "Eukaryotic NAD+ Synthetase Qns1 Contains an Essential, Obligate Intramolecular Thiol Glutamine Amidotransferase Domain Related to Nitrilase," J Biol Chem, v. 278, pp. 33049-33055 (2003). Download pdf PDF iconreprint
  44. P. Bieganowski & C. Brenner, "The Reported Human NADsyn2 is Ammonia-Dependent NAD+ synthetase from a Pseudomonad," J Biol Chem, v. 278, pp. 33056-33059 (2003). Download pdfPDF iconreprint
  45. C. Brenner, "Subtleties Among Subtilases: Structural Biology of Kex2 and Furin-Related Prohormone Convertases,"EMBO Reports, v. 4, pp. 937-938 (2003). Download pdf PDF iconreprint
  46. D.A. Kwasnicka, A. Krakowiak, C. Thacker, C. Brenner & S.R. Vincent, " Coordinate Expression of NADPH-Dependent Flavin Reductase, FRE-1, and Hint-Related 7meGMP-Directed Hydrolase, DCS-1," J Biol Chem, v. 278, pp. 39051-39058 (2003). Download pdf PDF iconreprint
  47. A. Krakowiak, H.C. Pace, G. Michael Blackburn, M. Adams, A. Mekhalfia, R. Kaczmarek, J. Baraniak, W.J. Stec & C. Brenner, "Biochemical, Crystallographic and Mutagenic Characterization of Hint, the AMP-Lysine Hydrolase, with Novel Substrates and Inhibitors," J Biol Chem, v. 279, pp. 18711-18716 (2004). View Hint-N-ethylsulfamoyl adenosine at the Protein Data Bank. Download pdf PDF iconreprint
  48. C. Brenner, "Precariously on the Cusp of Oncogenomics," chapter 1 of Oncogenomics: Molecular Approaches to Cancer, C. Brenner and D. Duggan, Eds., John Wiley & Sons, (2004). View the Oncogenomics PDF iconposter the site at Wiley, or Amazon. Download pdf PDF iconbook review in the New England Journal of MedicinePDF iconNEJMreview.pdf
  49. T.M. Maiolatesi & C. Brenner, "Chemical and Genetic Methods to Validate Targets in Non-Mammalian Organisms," chapter 10 of Oncogenomics: Molecular Approaches to Cancer, C. Brenner and D. Duggan, Eds., John Wiley & Sons, (2004). View the Oncogenomics PDF iconposter, the site at Wiley, or Amazon. Download pdf PDF iconbook review in the New England Journal of Medicine.
  50. P. Bieganowski & C. Brenner, "Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans," Cell, v. 117, pp. 495-502 (2004). Download pdf PDF iconreprint
  51. P. Bieganowski, K. Shilinski, P.N. Tsichlis & C. Brenner, "Cdc123 and Checkpoint Forkhead Associated With RING Proteins Control the Cell Cycle By Controlling eIF2gamma Abundance, " J Biol Chem, v. 279, pp. 44656-44666 (2004). Download pdf PDF iconreprint
  52. C. Brenner, "Chemical Genomics in Yeast," Genome Biology, v. 5, 240 (2004). Download pdf PDF iconreprint
  53. P.M. Clements, C. Breslin, E.D. Deeks, P.J. Byrd, L. Ju, P. Bieganowski, C. Brenner, M.-C. Moreira, A.M.R. Taylor & K.W. Caldecott, "The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4," DNA Repair, v. 3, pp. 1493-1502 (2004). Download pdf PDF iconreprint
  54. K.P. Parks, H. Seidle, N. Wright, J.B. Sperry, P. Bieganowski, K. Howitz, D.L. Wright & C. Brenner, "Altered Specifity of Hint-W123Q Supports a Role for Hint Inhibition by Asw in Avian Sex Determination," Physiological Genomics, v. 20, pp. 12-14 (2004). Download pdf PDF iconreprint and PDF iconsupplemental data
  55. T.-F. Chou, P. Bieganowski, K. Shilinski, J. Cheng, C. Brenner & C.R. Wagner, "31P NMR and Genetic Analysis Establish hinT as the only E. coli Purine Nucleoside Phosphoramidase and as Essential for Growth Under High Salt Conditions," J Biol Chem, v. 280, pp. 15356-15361 (2005). Download pdf PDF iconchou05.pdfPDF iconchou05.pdfPDF iconchou05.pdfPDF iconchou05.pdfPDF iconreprintand PDF iconsupplemental data
  56. H.F. Seidle, P. Bieganowski & C. Brenner, "Disease-Associated Mutations Inactivate AMP-Lysine Hydrolase Activity of Aprataxin," J Biol Chem, v. 280, pp. 20927-20931 (2005). View or PDF icon<img alt="PDF icon" class="file-icon" src="https://brenner.lab.uiowa.edu/modules/file/icons/application-pdf.png" title="application/pdf">download JBC Paper of the Week Summary. Download pdf PDF iconseidle05.pdfPDF iconseidle05.pdfPDF iconseidle05.pdfPDF iconseidle05.pdfPDF iconreprintand PDF iconsupplemental data
  57. C. Brenner, "Evolution of NAD Biosynthetic Enzymes," Structure, v. 13, pp. 1239-1240 (2005). Download pdf PDF iconreprint
  58. K.L. Bogan & C. Brenner, "Fhit," AfCS-Nature Molecule Pages (2006), [doi:10.1038/mp.a000914.01].
  59. S.K. Milano, Y.-M. Kim, F.P. Stefano, J.L. Benovic & C. Brenner, "Nonvisual Arrestin Oligomerization and Cellular Localization are Regulated by Inositol Hexakisphosphate Binding," J Biol Chem, v. 281, pp. 9812-9823 (2006). View Arrestin-2-IP6 entry at the Protein Data Bank. Download pdf PDF iconreprint and PDF iconsupplemental data
  60. J. Martin, F. Magnino, K. Schmidt, A.-C. Piguet, J.-S. Lee, D. Semela, M.V. St-Pierre, A. Ziemiecki, D. Cassio, D. Mochly-Rosen, C. Brenner, S.S. Thorgeirsson & J.-F. Dufour, "Hint2, a Mitochondrial Apoptotic Sensitizer Downregulated in Hepatocellular Carcinoma," Gastroenterology, v. 130, pp. 2179-2188 (2006). Download pdf PDF iconreprint
  61. P. Bieganowski, H.F. Seidle, M. Wojcik & C. Brenner, "Synthetic Lethal and Biochemical Analyses of NAD and NADH Kinases in Saccharomyces cerevisiae Establish Separation of Cellular Functions," J Biol Chem, v. 281, pp. 22439-22445 (2006). Download pdf PDF iconreprint
  62. A.B. Parsons, A. Lopez, I.E. Givoni, D.E. Williams, C.A. Gray, J. Porter, G. Chua, R. Sopko, R.L. Brost, C.-H. Ho, J. Wang, T. Ketela, C. Brenner, J.A. Brill, G.E. Fernandez, T.C. Lorenz, G.S. Payne, S. Ishihara, Y. Ohya, B. Andrews, T.R. Hughes, B.J. Frey, T.R. Graham, R.J. Andersen & C. Boone, "Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast," Cell, v. 126, pp. 611-6255 (2006). Download pdf PDF iconreprint. Examine supplementary data.
  63. M. Wojcik, H.F. Seidle, P. Bieganowski & C. Brenner, "Glutamine-Dependent NAD+ synthetase: How a Two-Domain, Three-Substrate Enzyme Avoids Waste," J Biol Chem, v. 281, pp. 33395-33402 (2006). Download pdf PDF iconreprint
  64. P. Belenky, K.L. Bogan & C. Brenner, "NAD+ Metabolism in Health and Disease," Trends in Biochemical Sciences, v. 32, pp. 12-19 (2007). Download pdf PDF iconreprint
  65. C.L. Linster, T.A. Gomez, K.C. Christensen, L.N. Adler, B.D. Young, C. Brenner & S.G. Clarke, "Arabidopis VTC2 Encodes GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants," J Biol Chem, v. 282, pp. 18879-18885 (2007). Download pdf PDF iconreprintView or PDF icondownload JBC Paper of the Week Summary.
  66. P. Belenky, F.G. Racette, K.L. Bogan, J.M. McClure, J.S. Smith & C. Brenner, "Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+," Cell, v. 129, pp. 473-484 (2007). Download pdf PDF iconreprint and PDF iconsupplementary data. Read PDF iconLeading Edge Preview in Cell, Research Highlights in Nature and PDF iconSpotlight in ACS Chemical Biology.
  67. M.E. Robu, J.D. Larson, A. Nasevicius, S. Beiraghi, C. Brenner, S.A. Farber & S.C. Ekker, "p53 Activation by Knockdown Technologies," PLOS Genetics, v. 3, issue 5, e78 (2007). Download pdf PDF iconreprint.
  68. C. Brenner, "Histidine Triad (HIT) Superfamily," Encyclopedia of Life Sciences, (2007), John Wiley & Sons, Ltd: Chichester.
  69. W. Tempel, W.M. Rabeh, K.L. Bogan, P. Belenky, M. Wojcik, H.F. Seidle, L. Nedyalkova, T. Yang, A.A. Sauve, H.-W. Park & C. Brenner, "Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD+," PLoS Biology, v. 5, issue 10, e263 (2007). View Nrk1-ADPNrk1-NRNrk1-AppNHp+NRNrk1-NMN, and Nrk1-tiazofurin entries at the Protein Data Bank. Download pdf PDF iconreprint and supporting information.
  70. R.S. Fuller, R.A. Bambara, T. Baker, B. Funnell, E. Wahle, M. O'Donnell, D. Kaiser, K. Skarstad, B. Konforti, S. Maki, T. Katayama, K. Sekimizu, J.H. Weiner, R.W. Davis, L. Rowen, M.F. Goodman, J. Spudich, S. Pfeffer, C.C. Richardson, P. Polaczek, R. Calendar, R. Kolodner, J. Griffith, B. Stillman, P. Modrich, C. Brenner & C. Yanofsky, "A Tribute to Arthur Kornberg, 1918-2007," Nat Struct Mol Biol, v. 15, pp. 2-17 (2008). Download pdf PDF iconreprint
  71. G.L. Loring, K.C. Christensen, S.A. Gerber & C. Brenner, "Yeast Chfr Homologs Retard Cell Cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-Dependent Ubiquitination," Cell Cycle, v. 7, pp. 95-105 (2008). Download pdf PDF iconloring08.pdfPDF iconloring08.pdfPDF iconloring08.pdfPDF iconloring08.pdfPDF iconreprintand PDF iconsupplementary data
  72. P.A. Belenky, T.G. Mogu & C. Brenner, "S. cerevisiae YOR071C Encodes the High Affinity Nicotinamide Riboside Transporter, Nrt1," J Biol Chem, v. 283, pp. 8075-8079 (2008). Download pdf PDF iconreprint and PDF iconsupplementary data
  73. K.L. Bogan & C. Brenner, "Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition," Ann Review Nutrition, v. 28, pp. 115-130 (2008). Download pdf PDF iconreprint
  74. C.L. Linster, L.T. Adler, K. Webb, K.C. Christensen, C. Brenner & S.G. Clarke, "A Second GDP-L-Galactose Phosphorylase in Arabidopsis en Route to Vitamin C: Covalent Intermediate and Substrate Requirements for the Conserved Reaction," J Biol Chem, v. 283, pp. 18483-18492 (2008). Download pdf PDF iconreprint
  75. L. Brooks,III, E.G. Heimsath, Jr., G.L. Loring & C. Brenner, "FHA-RING Ubiquitin Ligases in Cell Division Cycle Control," Cell Mol Life Sci, v. 65, cover and pp. 3458-3466 (2008). Download pdf PDF iconreprint
  76. P. Belenky, K.C. Christensen, F. Gazzaniga, A.A. Pletnev & C. Brenner, "Nicotinamide Riboside and Nicotinic Acid Riboside Salvage in Fungi and Mammals: Quantitative Basis for Urh1 and Purine Nucleoside Phosphorylase Function in NAD+ Metabolism," J Biol Chem, v. 284, pp. 158-164 (2009). Download pdf PDF iconreprint
  77. P. Bieganowski & C. Brenner, "Nicotinamide Riboside Kinase Compositions and Methods for Using the Same,"Australian Patent 2005211773, issued June 1, 2009. 
  78. F. Gazzaniga, R. Stebbins, S. Z. Chang, M.A. McPeek & C.Brenner, "Microbial NAD Metabolism: Lessons from Comparative Genomics, "Microbiol Mol Biol Rev, v. 73, pp. 529-541 (2009). Download pdf PDF iconreprint
  79. K.L. Bogan, C. Evans, P. Belenky, P. Song, C.F. Burant, R.T. Kennedy & C. Brenner, " Identification of Isn1 and Sdt1 as Glucose and Vitamin-regulated NMN and NaMN 5'-nucleotidases Responsible for Production of Nicotinamide Riboside and Nicotinic Acid Riboside," J Biol Chem, v. 284, pp. 34861-34869 (2009). Download pdf PDF iconreprint and PDF iconsupplementary datat.
  80. C. Evans, K.L. Bogan, P. Song, C.F. Burant, R.T. Kennedy & C. Brenner, "NAD+ Metabolite Levels as a Function of Vitamins and Calorie Restriction: Evidence for Different Mechanisms of Longevity," BMC Chem Biol, v. 10, 2 (2010). Download pdf PDF iconreprint and PDF iconsupplementary data
  81. K.L. Bogan & C. Brenner, "5'-Nucleotidases and their New Roles in NAD+ and Phosphate Metabolism," New Journal of Chemistry, v. 34, pp. 845-853 (2010). Download pdf PDF iconreprint
  82. F. Syeda, R.L. Fagan, M. Wean, G.V. Awakumov, J.R. Walker, S. Xue, S. Dhe-Paganon & C. Brenner, "The RFTS Domain is a DNA-Competitive Ingibitor of Dnmt1," JBC, v. 286, pp. 15344-15351 ( 2011). Download pdf PDF iconreprint
  83. C. Brenner. "On the Nonspecific Degradation of NAD+ to Nicotinamide Riboside," JBC, v. 286, p. le5 (2011). Download pdf PDF iconreprint
  84. P. Belenky, R. Stebbins, K.L. Bogan, C.R. Evans & C. Brenner, "Nrt1 and Tna1-Independent Export of NAD+ Precursor Vitamins Promotes NAD+ Homeostasis and Allows Engineering of Vitamin Production," PLoS ONE, v. 6, p. e19710 (2011). Download pdf PDF iconreprint
  85. J. Boylston & C. Brenner, "FHIT," Encyclopedia of Signaling Molecules, S. Choi, ed, chapter 68, part 7, pp. 613-616 (2012). DOI: 10.1007/978-1-4419-0461-4_68. Download pdf PDF iconreprint
  86. C. Brenner, P. Belenky & K.L. Bogan, "Yeast Strain and Method for Using the Same to Produce Nicotinamide Riboside," US Patent 8,114,626, issued February 14, 2012. Download pdf PDF iconreprint
  87. C. Brenner & D. Ringe, "Response to the New MCAT: ASBMB Premedical Curriculum," ASBMB Today, v. 11, pp. 12-14 (2012). Download pdf PDF iconreprint
  88. R.R. Midtkandal, P. Redpath, S.A.J. Trammell, S.J.F. Macdonald, C. Brenner & M.E. Migaud, "Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside," Bioorganic & Medicinal Chemistry Letters v. 22, pp. 5204-7 (2012). Download pdf PDF iconreprint
  89. C. Brenner, "Nicotinamide riboside kinase compositions and methods for using the same," US Patent 8,197,807, issued June 12, 2012. Download pdf PDF iconreprint
  90. C. Brenner, "Changes in Chemistry and Biochemistry Education:  Creative Responses to MCAT Revisions in the Age of the Genome," Biochem and Mol Biol Education, v. 41, pp. 1-4 (2013). Download pdf PDF iconreprint
  91. C. Brenner, "Nicotinamide riboside kinase compositions and methods for using the same," US Patent 8,383,086, issued February 26, 2013. Download pdf PDF iconreprint
  92. K.L. Bogan & C. Brenner, "Biochemistry: Niacin/NAD(P)," Encyclopedia of Biological Chemistry, W.J. Lennarz & M.D. Lane, eds., v. 3, pp.172-178, (2013), Waltham, MA: Academic Press. Download pdf PDF iconreprint
  93. S.A.J. Trammell & C. Brenner, "Targeted, LCMC-Based Metabolomics for Quantitative Measurement of NAD+ Metabolites," Computational and Structural Biotechnology Journal, v. 4, e201301012 (2013). DOI: 10.5936/csbj.201301012. Download pdf PDF iconreprint.
  94. C. Brenner, "Rethinking Premedical and Health Professional Curricula in Light of MCAT 2015," Journal of Chemical Education, v. 90, pp. 807-812 (2013). DOI:10.1021/ed4002738. Download pdf PDF iconreprint
  95. R.L. Fagan, D.E. Cryderman, L. Kopelovich, L.L. Wallrath & C. Brenner, "Laccaic Acid A is a Direct, DNA-Competitive Inhibitor of DNA Methyltransferase 1," J Biol Chem, v.288, pp. 23858-23867 (2013). DOI: 10.1074/jbc.M113.480517. Download pdf PDF iconreprint.
  96. C. Brenner, "Demystifying the Chalk Talk," ASBMB Today, v. 12, number 8, pp. 33-35 (2013). Download pdf PDF iconreprint
  97. S. Ghanta, R.E. Grossmann & C. Brenner, "Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications"  Critical Rev Biochem & Mol Biol, v. 48, pp. 561-574 (2013). Download pdf PDF iconreprint.
  98. P.J. Kennelly, J.S. Bond, B.S. Masters, E.A. Dennis, C. Brenner & D.M. Raben, "Desperately Seeking Flexner: Time to Reemphasize Basic Science in Medical Education" Academic Medicine, v. 88, pp. 1405-1406 (2013). DOI: 10.1097/ACM.0b013e3182a225be. Download pdf PDF iconreprint
  99. R.L. Fagan, M. Wu, F. Chédin & C. Brenner, "An Ultrasensitive High Throughput Screen for DNA Methyltransferase 1-targeted Molecular Probes" PLoS One, v. 11,e78752 (2013). Download pdf PDF iconreprint.
  100. S-C. Mei & C. Brenner, “NAD as a Genotype-Specific Drug Target” Chemistry & Biology, v. 20, pp. 1307-1308 (2013). Download pdf PDF iconreprint
  101.  J. Huang, A. Stewart, B. Maity, J. Hagen, R.L. Fagan, J. Yang, D.E. Quelle, C. Brenner & R.A. Fisher, "RGS6 Suppresses Ras-inducded Cellular Transformation by Facilitating Tip60-mediated Dnmt1 Degradation and Promoting Apoptosis,"Oncogene, v. 33, pp. 3604-11 (2014). DOI:10.1038/onc.2013.324. Download pdf PDF iconreprint
  102.  C. Brenner, “Understanding Faculty Salaries,” ASBMB Today, v. 13, number 1, pp. 28-29 (2014). Download pdf PDF iconreprint
  103.  C. Brenner, “Metabolism: Targeting a fat-accumulation gene” Nature, v. 508, pp. 194-195 (2014). DOI: 10.1038/508194a. Download pdf PDF iconreprint.
  104. C. Brenner, "Histidine Triad Superfamily" Encyclopedia of Life Sciences, John Wiley & Sons Ltd: Chichester (2014).  DOI: 10.1002/9780470015902.a0020545.pub2.
  105. J.A. Boylston & C. Brenner, "A Knockdown with Smoke Model Reveals Fhit as a Repressor of Heme Oxygenase 1," Cell Cycle, v. 13, pp. 2913-30 (2014). DOI:10.4161/15384101.2014.946858. Download pdf PDF iconreprint
  106. B.-K. Wu, S.-C. Mei & C. Brenner, "RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation," Cell Cycle, v. 13, pp. 3222-3231 (2014). DOI:10.4161/15384101.2014.950886. Download pdf PDF iconreprint
  107. S.-C. Mei & C. Brenner, "Quantification of Protein Copy Number in Yeast: the NAD+ Metabolome," PLoS One v. 9, e106496 (2014). DOI: 10.1371/journal.pone.0106496. Download pdf PDF iconreprint
  108. B.-K. Wu & C. Brenner, “Suppression of TET1-Dependent DNA Demethylation is Essential for KRAS-Mediated Transformation,” Cell Reports, v. 9, pp. 1827-1840 (2014). DOI:10.1016/j.celrep.2014.10.063. Download pdf PDF iconreprint
  109. C. Brenner, “Boosting NAD to Spare Hearing,” Cell Metabolism, v. 21, pp.926-927 (2014). DOI: 10.1016/j.cmet.2014.11.015. Download pdf PDF iconreprint.
  110.  S.-C. Mei & C. Brenner, "Calorie Restriction-Mediated Replicative Lifespan Extension in Yeast Is Non-Cell Autonomous," PLoS Biology, v. 13, e1002048 (2015). Download pdf PDF iconreprint
  111. S.A.J. Trammell & C. Brenner, “NNMT: A Bad Actor in Fat Makes Good in Liver,” Cell Metabolism, v. 22, pp. 200-201 (2015). DOI:10.1016/j.cmet.2015.07.017. Download pdf PDF iconreprint
  112. S.A.J. Trammell, L. Yu, P. Redpath, M.E. Migaud & C. Brenner, "Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk," The Journal of Nutrition, v. 146, pp. 957-963 (2016). DOI: 10.3945/jn.116.230078. Download pdf PDF iconreprint
  113. S.A.J. Trammell, B.J.Weidemann, A.Chadda, M.S. Yorek, A. Holmes, L.J.Coppey, A. Obrosov, R.H. Kardon, M.A. Yorek & C. Brenner, “Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice,” Scientific Reports, v. 6, 26933 (2016). DOI: 10.1038/srep26933. Download pdf PDF iconreprint
  114. S.A.J Trammell, M.S. Schmidt, B.J. Weidemann, P. Redpath, F. Jaksch, R.W. Dellinger, Z. Li, E.D. Abel, M.E. Migaud & C. Brenner, "Nicotinamide riboside is uniquely and orally bioavailable in mice and humans." Nat Commun. v. 7, pp. 12948 (2016). DOI: 10.1038/ncomms12948. Download pdf reprint
  115. J. Ratajczak, M. Joffraud, S.A.J. Trammell, R. Ras, N. Canela, M. Boutant, S.S. Kulkarni, M. Rodrigues, P. Redpath, M.E. Migaud, J. Auwerx, O. Yanes, C. Brenner & C. Canto, "NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells." Nat Commun. v. 7, pp. 13103. DOI: 10.1038/ncomms13103. Download pdf reprint.
  116. J.L. Wilsbacher, M. Cheng, D. Cheng, S.A.J. Trammell, Y. Shi, J. Guo, S.L. Koeniger, P.J. Kovar, Y. He, S. Jagadeeswaran, H.R. Heyman, B.K. Sorensen, R.F. Clark, T.M. Hansen, K.L. Longenecker, D. Raich,  A.V. Korepanova, D.L. Towne, V.C. Abraham, H. Tang, S.M. McLoughlin, M.L. Curtin, M.R. Michaelides, D. Maag, F.G. Buchanan, W. Gao, S.H. Rosenberg, C. Brenner & C. Tse, “Discovery and Characterization of Novel, Orally Bioavailable Non-substrate and Substrate NAMPT Inhibitors,” Molecular Cancer Therapeutics, in press, 2017.
  117. M.V. Hamity, S.R. White, R.Y. Walder, M.S. Schmidt, C. Brenner & D.L. Hammond, “Nicotinamide Riboside, a Form of Vitamin B3 and NAD+ Precursor, Relieves the Nociceptive and Aversive Dimensions of Paclitaxel-induced Peripheral Neuropathy in Female Rats,” Pain, in press, 2017. DOI: 10.1097/j.pain.0000000000000862

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